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Determination of resorcinol conjugates in the h urine samples after 14 days of continuous product treatment confirmed that a maximal 23 mg 2. Assuming a body weight of sixty four kg IPCS, provides an exposure estimate of zero. In based on shopper analysis information Gans, , under affordable maximum-use situations i.

Resorcinol is understood to form covalent bonds with haem Sessler et al. Effects on the thyroid gland have been reported each in animal research and in case-reviews in humans. However, there are species differences within the susceptibility to goitrogens.
The bulk of the urine-recovered dye must have been taken up into the attractive layer of the skin and then slowly released into the circulation. A cumulative four-day absorption assuming cm 2 of scalp was given as zero.

In , medical examinations see above and thyroid assessments had been carried out with of presumably lively plant employees men and 33 girls. Flaked resorcinol triggered no perceptible to moderate irritation intact pores and skin or no perceptible necrosis abraded skin.

  • In addition, male rats have greater circulating ranges of TSH than females.

  • Of the following research, the repeated-dose toxicity research that had been deemed to be most related to the risk assessment are summarized in Appendix 6.

  • In the body of a full life cycle toxicity test OECD TG , Lima noticed no adverse results after 48 h of exposure on the highest concentration examined, 0.

  • In in vitro genotoxicity tests, resorcinol showed largely adverse results.

  • In both species, there were no opposed effects on final mean body weights, haematology, or clinical chemistry parameters, and no chemical-associated gross or microscopic lesions have been observed.

There are variations in thyroid physiology between humans and animals. The weight of evidence suggests that rodents are extra delicate to thyroid effects than humans.

According to the results obtained, Daphnia magna is essentially the most delicate organism, and resorcinol can be classified as acutely poisonous only to Daphnia. However, this worth is questionable for use as a limit worth in threat assessment this is the highest concentration tested on this research , and the NOEC might be significantly higher than stated in the study. In the environment, resorcinol is rapidly degraded half-life about 2 h by response with photochemically produced hydroxyl radicals. Under cardio circumstances, resorcinol proved to be readily biodegradable in a check carried out based on OECD TG C, and it's prone to be biodegraded under anaerobic conditions.

From its use in topical medication and from restricted data from occupational research, resorcinol doesn't look like irritating to the skin in the concentrations reported. Van Leeuwen et al. There isn't any indication as to whether the teratogenic results were endocrine mediated or not EC, c. In people, dermal exposure to resorcinol has been reported to be related to thyroid results, CNS disturbances, red blood cell modifications, and a low incidence of skin sensitization. Five of three.

In in vitro human skin studies, resorcinol was evaluated from a representative hair dye formulation that contained 0. However, it should be considered that acned pores and skin could also be broken due both to scratching or to the blemishes themselves.